A highly effective atypical antipsychotic reserved for treatment-resistant schizophrenia due to its risk of agranulocytosis, a potentially fatal blood disorder. Requires regular blood monitoring.
Developed by Sandoz (now Novartis) in the 1960s, named for its chemical structure as a dibenzodiazepine compound. The '-ine' suffix is standard for nitrogen-containing pharmaceutical compounds.
Clozapine is the 'gold standard' for treatment-resistant schizophrenia, helping about 60% of patients who don't respond to other medications. However, it can destroy infection-fighting white blood cells, so patients need weekly blood tests - this monitoring system has prevented thousands of deaths while allowing access to this life-changing medication.
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