Plural of epistler; people who write epistles or letters, especially formal or official ones.
From epistle (a letter, especially a formal one) plus the agent suffix -er, making epistler one who writes epistles. The plural form adds -s. The term evolved from Middle English and Old French epistre, from Latin epistola.
Epistlers were especially common in the early Christian church, where letter-writing was how leaders communicated doctrine across distant communities—basically the email system of the ancient world, except Paul's epistles became scripture!
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