A surgical transplant of tissue or an organ from one species to a different species, such as transplanting a pig heart into a human.
From Greek 'hetero-' (different) combined with 'transplant' (to move tissue from one place to another). This medical term emerged in the 20th century as transplantation surgery advanced.
Xenotransplantation (using animals) might sound futuristic, but the first heterotransplant attempts happened in the 1600s when doctors tried to transfuse animal blood into humans—it didn't work, but it showed humans have always dreamed of mixing biology across species.
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